Helico is enabling the next generation of biologics using plant-based production of high-quality, environmentally-safe compounds. Our vision is to become a fully integrated biopharmaceutical company that improves access to therapies where there are global supply shortages or unmet production needs. Our work evolves in the area of advanced computational science and plant biology, leading to expression and the production of proteins, antibodies, and enzymes in host plants. Our business model aims to develop plant-based, stable production lines, delivering rapid, scalable eco-friendly commercial Contract Development and Manufacturing Organisation (CDMO) services in confined greenhouses that can be implemented anywhere in the world using conventional agriculture, without specialised staff or high capital expenditure.
First, we assess the compound of interest using Helico’s proprietary computational algorithms. Specifically trained on biological data, the model greatly speeds up geneticwork in plants. The target is then evaluated in the lab with HTS models based on transient expression. Once the target is validated, we move to the generation of stable lines, the final deliverable. What’s more, we’re developing extraction and purification methods to achieve the best commercial yields based on our clients' specifications.
Simulation on computers means less experimentation on living organisms
Targeted experiments in biolab validates computational models
Plants as the production model makes scalability easy and adaptable
Simplified processed to be adaptable worldwide
Employing mutational screening algorithms, we aim to predict the best method for plant-based production via novel biochemical pathways in the plant environment.
We do wet lab experiments to validate the expression of the molecule of interest in plants. Our development time is comparable to the work done on yeast and bacterial platforms.
We are collaborating with partners to develop tailor-made extraction and purification technologies.
Helico is designing computational and plant models to bring our clients’ targets through a successful manufacturing process: